delivers 1,000 mg of Berberine HCl per serving (500 mg per capsule) derived from Berberis aristata, commonly known as Indian Barberry, one of the richest natural sources of berberine, in a clean two-ingredient vegetarian capsule with no unnecessary excipients, designed to support healthy blood glucose and lipid metabolism, gastrointestinal health, and immune function through one of the most clinically studied and therapeutically versatile plant alkaloids in integrative medicine.

Berberine is a yellow isoquinoline alkaloid found in several plants used in traditional Ayurvedic and Chinese herbal medicine for centuries, including Berberis species (barberry), Coptis chinensis (goldenseal), and Hydrastis canadensis. Its modern clinical application is built on an extensive and rapidly expanding body of human clinical and preclinical research that consistently demonstrates meaningful effects on blood glucose regulation, insulin sensitivity, healthy lipid metabolism, and gastrointestinal microbial balance.

The primary mechanism through which berberine supports metabolic health is the activation of AMP-activated protein kinase (AMPK), a cellular energy sensor sometimes called the "metabolic master switch." When activated, AMPK promotes glucose uptake into cells, stimulates fat oxidation, inhibits hepatic glucose production, and improves insulin sensitivity through pathways that parallel the mechanism of certain pharmaceuticals used for blood glucose support, but through a distinct biochemical route. This metabolic activity makes berberine one of the most clinically discussed botanical compounds in functional and integrative medicine for blood sugar and metabolic health applications.

Beyond its metabolic applications, berberine's traditional use as a GI health botanical is supported by research demonstrating its effects on GI microbial balance and healthy bowel regularity, making it a multidimensional formula relevant across metabolic, gastrointestinal, and immune health contexts simultaneously.

At 1,000 mg per serving across two capsules, XYMOGEN Berberine delivers the dose most consistently studied in human clinical research. Formulated to exclude wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, GMO-derived ingredients, artificial colors, artificial sweeteners, and artificial preservatives. NSF GMP-certified XYMOGEN professional formula. 120 vegetarian capsules, 60 servings.

Key Benefits:

• Supports healthy blood glucose levels and insulin sensitivity via AMPK activation
• Supports healthy lipid metabolism including cholesterol and triglyceride balance
• Supports gastrointestinal health and healthy GI microbial balance
• Supports immune function through its botanical antimicrobial activity
• Supports healthy bowel regularity and GI motility
• Supports healthy body composition alongside diet and lifestyle changes
• Supports cardiovascular metabolic health markers
• 1,000 mg Berberine HCl per serving at the clinically studied dose
• Derived from Berberis aristata, a premium source of berberine alkaloids
• Clean two-ingredient vegetarian capsule with no fillers or unnecessary excipients
• Formulated to exclude gluten, dairy, soy, GMOs, and artificial ingredients
• NSF GMP-certified XYMOGEN professional formula

Berberine HCl — 1 g (from Berberis aristata, Indian Barberry root) — Berberine hydrochloride is the salt form of berberine, providing improved stability and consistent potency compared to free-base berberine. At 1,000 mg per serving (500 mg per capsule), this delivers the dose used in the majority of published clinical research on berberine's metabolic and gastrointestinal effects. Berberis aristata, Indian Barberry, is one of the richest naturally occurring sources of berberine alkaloids and has been used as a medicinal plant in traditional Ayurvedic medicine for centuries for its metabolic, GI, and antimicrobial properties.

The primary metabolic mechanism is AMPK activation: berberine binds to and activates AMP-activated protein kinase, which stimulates glucose transporter expression (GLUT4) in muscle cells, inhibits gluconeogenesis in the liver, promotes fatty acid oxidation, and improves peripheral insulin receptor sensitivity. These combined effects support healthy blood glucose uptake and metabolism in a multifactorial manner consistent with the complexity of metabolic health.

Berberine also exerts broad-spectrum antimicrobial activity in the GI tract, supporting healthy microbial balance and bowel regularity through effects on both bacterial motility and secretory function. Its immune-supporting activity reflects the same broad-spectrum botanical antimicrobial properties that have made berberine-containing plants central to traditional medicine systems across cultures for their infection-fighting and GI-protective applications.

Other Ingredients: Capsule (hypromellose and water), dicalcium phosphate, ascorbyl palmitate, silica. Vegetarian capsule. No other active ingredients.

Store in a cool, dry place. Keep out of reach of children.

Adults: Take 2 capsules twice daily, or as directed by your healthcare professional.

Best taken with meals to minimize GI discomfort and support absorption alongside dietary carbohydrates and fats.

Consult your healthcare professional before use. Individuals taking medication should discuss potential interactions with their healthcare professional. Not recommended during pregnancy or breastfeeding. Do not use if tamper seal is damaged.