Liposomal Pregnenolone

delivers 50 mg of naturally-derived pregnenolone sourced from wild yam in a phosphatidylcholine liposomal delivery system from non-GMO sunflower oil, providing the body's master precursor steroid hormone in a highly bioavailable liquid format designed for practitioners working with hormonal balance, adrenal support, neurological health, and healthy aging.

Pregnenolone is produced primarily in the adrenal glands from cholesterol and occupies the most upstream position in the entire steroid hormone cascade. It is the precursor molecule from which the body synthesizes every major steroid hormone, including progesterone, DHEA, testosterone, estrogen, and cortisol. This upstream position makes pregnenolone uniquely influential across the entire hormonal network without carrying the androgenic, estrogenic, or anabolic activity of the downstream hormones it produces. Supplementing pregnenolone can support the steroid hormone precursor pool without directly driving any single downstream hormone, allowing the body's own enzymatic systems to direct synthesis toward whichever pathways are most needed based on its current physiological state.

What makes pregnenolone particularly compelling beyond its hormonal precursor role is its neurosteroid function. Human studies consistently show that pregnenolone is found in nervous tissue and the brain in concentrations significantly higher than those in the bloodstream, and both pregnenolone and DHEA are classified as neurosteroids, steroid hormones that act directly on the nervous system. In the brain, pregnenolone modulates GABA and NMDA receptors, supports neuronal health, and has been studied for its role in cognitive function, memory, and mood regulation independent of its peripheral hormonal effects.

DesBio's pregnenolone is produced from an ingredient extracted from wild yam, a plant-based source that provides the diosgenin precursor used to produce bioidentical pregnenolone. The phosphatidylcholine liposomal delivery system from non-GMO sunflower oil encapsulates the fat-soluble pregnenolone molecule in phospholipid vesicles that mirror cell membrane structure, enabling superior absorption and cellular delivery compared to standard pregnenolone capsules or tablets.

This product should be used under the guidance of a qualified healthcare practitioner. Pregnenolone is a steroid hormone precursor and influences the entire hormonal cascade. Lab testing (such as DUTCH testing or serum steroid hormone panels) is strongly recommended before and during use to guide appropriate dosing. Non-GMO sunflower lecithin base. Approximately 30 servings at 2 mL daily. Refrigerate after opening.

Key Benefits:

• Supports the steroid hormone precursor pool as the master upstream hormone in the cascade
• Supports progesterone, DHEA, cortisol, testosterone, and estrogen synthesis capacity
• Supports neurological health as a brain neurosteroid in concentrations higher than in the bloodstream
• Supports cognitive function, memory, and mood via GABA and NMDA receptor modulation
• Supports adrenal hormone production and HPA axis resilience
• Supports healthy aging through precursor hormone replenishment
• Supports healthy energy, mood, and stress resilience
• Plant-derived from wild yam, naturally-derived source
• Liposomal phosphatidylcholine delivery for superior absorption over capsule or tablet pregnenolone
• Practitioner-supervised use recommended with lab testing

What's Inside — Full Supplement Facts (per 2 mL / 40 drops serving):

Pregnenolone (from Wild Yam) — 50 mg — Naturally-derived pregnenolone produced from diosgenin extracted from wild yam root, converted to bioidentical pregnenolone through established pharmaceutical synthesis. Pregnenolone is the master precursor steroid hormone synthesized from cholesterol in the adrenal glands, brain, liver, skin, and gonads. It sits at the top of the steroidogenic cascade, providing the substrate from which progesterone, DHEA, testosterone, estrogen, and cortisol are all synthesized. As a neurosteroid, pregnenolone acts directly on the nervous system through modulation of GABA-A receptors (inhibitory, calming effect) and NMDA receptors (excitatory, cognitive effect), supporting balanced neurological function, memory consolidation, and mood regulation at concentrations found naturally in the brain far exceeding peripheral blood levels.

Liposomal Proprietary Blend (Phosphatidylcholine from non-GMO Sunflower Oil, Glycerine Complex) — 450 mg — A non-soy phosphatidylcholine liposomal delivery system from sunflower lecithin that encapsulates pregnenolone in phospholipid vesicles mimicking cell membrane structure. Pregnenolone is a fat-soluble steroid hormone that benefits significantly from lipid-based delivery systems that protect it from digestive degradation and enhance its absorption into systemic circulation. The glycerine complex provides liquid base stability.

Other Ingredients: Demineralized water, 25% ethanol (as tincture base and natural preservative).

Storage

Refrigerate after opening. Avoid excessive heat. Keep out of reach of children.

Directions

Take 2 mL (approximately 40 drops) per day, or as directed by your healthcare professional. May be mixed into 1 to 2 ounces of juice. Best taken in the morning to align with the body's natural steroid hormone production window.

This product should be used under the supervision of a qualified healthcare practitioner with appropriate hormone testing. If you are pregnant, nursing, taking medications including hormonal therapies or corticosteroids, or have a hormone-sensitive condition, consult your healthcare provider before use.

Liposomal Pregnenolone by DesBio is a practitioner-formulated liposomal hormone precursor supplement available at SOLUDE Wellness & Beauty. It contains Pregnenolone (from Wild Yam) 50 mg and Liposomal Proprietary Blend (Phosphatidylcholine from non-GMO Sunflower Oil, Glycerine Complex) 450 mg per 2 mL serving (40 drops), in demineralized water and 25% ethanol. It is designed to support the steroid hormone precursor pool as the master upstream hormone, support progesterone, DHEA, cortisol, testosterone, and estrogen synthesis capacity, support neurological health and cognitive function as a brain neurosteroid, support mood, memory, and adrenal hormone production, and support healthy aging through precursor hormone replenishment. Non-GMO sunflower phosphatidylcholine liposomal delivery for superior absorption. Wild yam-derived, naturally-derived source. Practitioner supervision and lab testing recommended. Refrigerate after opening. Approximately 30 servings at 2 mL daily.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.